Systemic Lupus Erythematosus (SLE) is a chronic inflammatory disease which is a chronic inflammatory disease which results from an immune regulatory disturbance brought about by the interplay of genetics ,hormonal and environmental factors .It is primarily a disease of young women having a peak incidence occurrence between the age of 10 and 50 with a female ratio of 9:1,This is due to the presence of two X chromosomes in the female as opposed to the one X chromosomes present in males, The X chromosomes carries immunological related genes, which can mutate and contribute to the onset of SLE.The Y chromosomes has no identified mutations associated with autoimmune disease.
The underline cause is not known and SLE prevalence varies by racial and ethnic group and social status.
WHAT DO YOU THINK CAN CAUSE IT?
Though the underline cause is not known, but there are factors that can flare it up.
- Genetic factor: SLE can be inherited specially from first degree relatives (mother, father, brother, sisters) of people with lupus have an eight fold to nine fold increased risk of having compared with the general public.
- Environmental factors: Sun exposure (ultra violet light) is a known environmental agent that can worsen rashes of patients with lupus and sometimes trigger a flare of the entire disease.
- Drugs e.g. Hydralazine, Quinidine, procanamide can also stimulate the disease.
SLE seems to result from a disturbance of immune regulation that result from a polyclonal activation of B cells causing an exaggerated production of auto antibodies and may also result from interplay of genetics, environmental, and hormonal factors.
SIGNS AND SYMPTOMS
- Joint pain and swelling
- Skin rash e.g. Butterfly rash
- Sensitivity to UV light
- Kidney abnormalities
- Psychosis and depression
CRITERIAS FOR DIAGNOSING LUPUS
The diagnosis of lupus is a clinical one made by observing symptoms. Laboratory tests provide only a part of the pictures. The American College of Rheumatology has designated 11 criteria for classification.
- Malar rash: This is a “butterfly- shaped” red rash over the cheeks below the eyes. It may be flat or a raised rash.
- Discoid rash: These are red, raised patches with scaling of the overlying skin. Subgroups of patients have “discoid lupus” with only skin involvement and do not have systemic involvement.
- Photosensitivity: A rash develops in response to sun exposure. This not to be confused with heat rash that develops in body folds or moist areas of the body with exposure to heat.
- Oral Ulcers: Painless sores in the nose mouth
- Arthritis: The Arthritis of lupus usually does not cause deformities of the joints. Swelling and tenderness must be present.
- Serotitis: This refers to an inflammation of various “Sac” or membranes that cover the lung cover the heart and line the abdomen. Inflammation of these tissues causes severe discomfort in the areas affected.
- Kidney disease (nephritis): There is persistent loss of protein in the urine or a microscopic analysis of urine has a particular cellular element referred to by pathologist as a “cast”.
- Neurological disorder: This can present as seizures or as a primary psychiatric disorder.
- Blood disorder: Low blood counts of various blood components are known to occur.
- Immunologic disorder: This requires special laboratory testing for specific markers of disease in lupus. These tests include antibodies to DNA, a nuclear protein or phospholipid cardiolipin antibodies that can react with the body’s own tissues is why lupus is called an autoimmune disease.
- Positive antinuclear antibody: A more general marker in the blood for the presence of an autoimmune disease, these “ANA” levels which increases by age. The ANA test is most useful when the result is negative which essential rules out the diagnosis of SLE, since up to 98% of people with lupus have a positive ANA test result.
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I appreciate your kind words. BTW If you (or ohters
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she was helped it wdouln\'t mean all that much, and this is why. Lupus is a disease that waxes and wanes. Good days and months and bad days and months. So until she\'s been on his treatment for a substancial period of time and has noted improvement this post means nothing. In fact it smacks of distortion.BTW the link to the YouTube video just takes you back to the Article of Faith site not a YT video. http://sujiapfg.com [url=http://trbasj.com]trbasj[/url] [link=http://ifqvqapud.com]ifqvqapud[/link]
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