Israel’s Defence Minister on Thursday issued a direct threat against Iran’s Supreme Leader, Ayatollah Ali Khamenei, accusing him of orchestrating attacks on Israel through proxy forces and calling for his elimination.

The minister’s remarks, reported by Al Jazeera, reflect growing tensions between the two countries following an Iranian missile strike on Beersheba, which reportedly caused damage to the Soroka Medical Center.

The minister stated that Khamenei has consistently sought Israel’s destruction, adding that preventing him from continuing his actions is now considered part of Israel’s broader campaign.

According to him, as reported by Al Jazeera, “A man like [Khamenei] has always aimed at destroying Israel through his agents.

“This man, who is willing to attack us, must not stay alive. This matter, the matter of stopping this man, eliminating him, is part of the campaign, and we now understand his role because before, he was talking about the destruction of Israel.”

In recent days, Israel has launched strikes on Iranian nuclear and military facilities, prompting retaliatory missile and drone attacks from Iran.

Israeli Prime Minister Benjamin Netanyahu recently addressed the Iranian people in a video message, expressing hope that military operations would help pave the way for Iranians to achieve freedom.

On Tuesday, President Donald Trump also weighed in on Khamenei, stating in a social media post: “We are not going to take him out (kill!), at least not for now… Our patience is wearing thin.”

Earlier, Khamenei warned the US that any strikes on its territory would have “serious irreparable consequences”.

As reported by Al Jazeera, the death toll from Israel’s attacks on Iran has risen to more than 240, including 70 women and children. At least 24 people have been killed in Iranian attacks on Israel.