Clare Akamanzi is a Rwandan lawyer, public administrator, businesswoman and politician, Clare Akamanzi serves as chief executive officer of the Rwanda Development Board, the Rwandan government cabinet agency tasked with helping oversee Rwanda’s business regulations, foreign investments, tourism promotion, environmental conservation, and broader economic and development planning. Akamanzi has also served as Rwanda’s trade negotiator to the World Trade Organization, as chair of the holding company overseeing several Rwandan aviation groups, and as head of Strategy and Policy in the office of Rwandan President Paul Kagame.

She began her career in 2004 in Geneva, Switzerland at the World Trade Organization (WTO) headquarters. The government of Rwanda appointed her as a diplomat/special trade negotiator at the WTO. Later, she transferred to the Rwandan embassy in London, the United Kingdom as the commercial diplomat (commercial attaché).

She returned to Rwanda in 2006 and was appointed Deputy Director General of the then Rwanda Investment and Export Promotion Agency (RIEPA) "before RDB was merged with other institutions in 2008". In 2008, Akamanzi became the Deputy Chief Executive Officer responsible for Business Operations and Services, at RDB. She later transitioned to being the Chief Operating Officer of the Rwanda Development Board. She then took study leave to pursue graduate studies in the United States. When she returned, she served as "Head of Strategy and Policy" in the President’s Office.